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WebFig. S5. Ibrutinib is more effective at targeting GSCs than NSTCs. Fig. S6. Ibrutinib treatment inhibits BMX-mediated STAT3 activation in GSCs. Fig. S7. Ectopic expression of constitutively active STAT3 largely rescues GSC maintenance disrupted by ibrutinib. Fig. S8. JAK2 mediates STAT3 activation in NPCs, whereas BMX interacts with Web15 jun. 2024 · GSCs and matched NSTCs were cultured in neurobasal media without supplements and growth factors for 40 h. Conditioned medium was collected from cultures at a density of 2 × 10 6 cells/mL. cybernetics means
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