WebCD276, also known as B7-H3, is a cell surface tumor endothelial marker that is highly expressed in the tumor vessels of human lung, breast, colon, endometrial, renal, and ovarian cancer, but not in the angiogenic vessels of healthy tissue. Web16 Sep 2024 · B7-H3 was recognized as a co-stimulatory molecule for immune reactions such as T cell activation and IFN-y production. In the presence of anti-CD3 antibody mimicking the TCR signal, human...
B7-H3 antibody (30052-1-AP) Proteintech
Web13 Mar 2024 · B7H3 expression is also detected on various normal tissues and in some tumor cell lines. Human B7H3 does not bind any known members of the CD28 family of … Web15 Jun 2002 · Human B7-H3 is among the most recently discovered B7-like molecules . Soluble human B7-H3 molecule was previously reported to bind to activated T cells and … historical architects maine
B7-H3 antibody (30052-1-AP) Proteintech
WebHuman B7-H3 has a single extracellular variable-type immunoglobulin (IgV)-IgC domain, a signature intracellular domain, and an additional isoform, known as 4Ig-B7-H3, … WebB7-H3 (CD276) is a type I transmembrane protein expressed on many tissues and cell types. B7-H3 is a 100-kDa glycoprotein that belongs to the B7 immunoregulatory family and participates in the regulation of T-cell-mediated immune response probably by functioning as both a T cell costimulator and coinhibitor (PMID: 25567370; 20696859). WebThe B7 family member B7-H3 is broadly expressed in many tissue and tumor types. B7-H3 expression is induced on some immune cells; however, its immunological function … historical architects in utah