Web5 de nov. de 2024 · Neural cell-specific Hif-1α deficient mice exhibit a hydrocephalus accompanied by a reduction of neuronal cells and an impairment of spatial memory, … Web29 de jul. de 2024 · Reinforces Important Progress in Merck’s Oncology Pipeline to Advance Novel Therapeutic Candidates Merck (NYSE: MRK), known as MSD outside the United States and Canada, announced today that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to the hypoxia-inducible factor-2 alpha …
JCI - Hypoxia-inducible factor 2α regulates macrophage function …
Web19 de set. de 2024 · We deleted HIF-2α in the NP tissue using a notochord-specific FoxA2 Cre allele to study HIF-2α function in the adult intervertebral disc. Unlike observations in HIF-1α cKO mice, fate mapping studies using Rosa26-mTmG reporter showed that HIF-2α loss in NP did not negatively impact cell survival or affect compartment development. Web19 de jul. de 2010 · Interestingly, HIF-2α is essential for proinflammatory cytokine expression, as the cytokine defect manifested in myeloid HIF-2α–deficient … list of musicians at woodstock
深度解析 2024 年诺贝尔生理学或医学奖:「HIF 通路」 ...
Web656MO - Phase II study of belzutifan (MK-6482), an oral hypoxia-inducible factor 2α (HIF-2α) inhibitor, plus cabozantinib for treatment of advanced clear cell renal cell carcinoma (ccRCC) Date 18 Sep 2024. Session Mini oral session - Genitourinary tumours, non-prostate. Topics Web6 de out. de 2024 · Hypoxia-inducible factor 1α (HIF-1α) and HIF-2α are master transcription factors that regulate cellular responses to hypoxia, but the exact function in regulatory T … Web23 de mar. de 2024 · In the kidney, HIF-1α and HIF-2α are the two main isoforms of HIF, with different expression sites. HIF-1α is mainly expressed in tubular epithelial cells, whereas HIF-2α expression is induced ... list of music hubs in the uk