WebThe NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874). … WebSep 25, 2024 · Here, we investigated the potential scaffold function of human CFD1 (NUBP2) in CFD1-depleted HeLa cells by measuring Fe-S enzyme activities or 55 Fe incorporation into Fe-S target proteins. We show that CFD1, in complex with NBP35 (NUBP1), performs a crucial role in the maturation of all tested cytosolic and nuclear Fe …
Molecular characteristics of proteins within the mitochondrial Fe-S ...
WebFeb 1, 2024 · NUBP2, NUBP1, and IOP1 are cytosolic Fe-S cluster assembly factors while CIAO1 facilitates the transfer of Fe-S clusters into extramitochondrial apoproteins (Stehling et al., 2008). An initial step is the assembly of a [4Fe-4S] cluster on the NUBP2-NUBP1 scaffold complex (summarized for yeast in ( Netz et al., 2007 )), aided by … Web{"numberOfHits":1,"results":[{"id":"GO:0051539","isObsolete":false,"name":"4 iron, 4 sulfur cluster binding","definition":{"text":"Binding to a 4 iron, 4 sulfur (4Fe ... can rock frying pans go in the oven
FlyBase Gene Report: Dmel\Nubp1
WebNX_Q9Y5Y2 - NUBP2 - Cytosolic Fe-S cluster assembly factor NUBP2 - Function. Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and … WebMar 29, 2024 · Biogenesis of iron-sulfur clusters (ISC) is essential to almost all forms of life and involves complex protein machineries. This process is initiated within the mitochondrial matrix by the ISC assembly machinery. Cohort and case report studies have linked mutations in ISC assembly machinery to severe mitochondrial diseases. The voltage … WebMar 1, 2024 · Here, we investigated the potential role of the human cochaperone HSC20 in cytosolic Fe-S assembly and found that HSC20 assists Fe-S cluster delivery to cytosolic and nuclear Fe-S proteins. Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the … can rocking chair induce labor